Betulinic Acid Ameliorates Cerebral Injury in Middle Cerebral Artery Occlusion Rats through Regulating Autophagy

Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease that caused by the sudden rupture of blood vessels inside brain and intervention reperfusion to brain, resulting in severe cerebral injury. Autophagy has been reported be involved occurrence progression CIS. Betulinic acid (BA) a pentacyclic triterpene mainly extracted from birch bark. Studies have shown neuroprotective effects BA. Here, effect mechanism BA on ischemia-reperfusion induced injury was explored using CIS model vivo via 1 h middle artery occlusion (MCAO) 24 rats vitro oxygen–glucose deprivation/reperfusion (OGD/R) PC12 cells, respectively. We found not only reduced reducing oxidative stress but also activated SIRT1/FoxO1 pathway suppress autophagy improve MCAO rats. These results provide basis for potential clinical application